954 MagneTEskin – Orientation matters

Bio012476 954..960

Homeodomain transcription factors regulate development of embryos and cellular physiology in adult systems. Paired-type homeodomain genes constitute a subclass that has been particularly implicated in establishment of neuronal identity in the mammalian nervous system. We isolated fragments of eight homeodomain genes of this subclass expressed in the stellate ganglion of the North Atlantic long ...

Dmd057265 954..962

Deuterium isotope effects were evaluated as a strategy to optimize the pharmacokinetics of 7-(3,5-dimethyl-1H-1,2,4-triazol-1-yl)-3-(4methoxy-2-methylphenyl)-2,6-dimethylpyrazolo[5,1-b]oxazole (NVSCRF38), a novel corticotropin-releasing factor receptor 1 (CRF1) antagonist. In an attempt to suppress O-demethylation of NVSCRF38 without losing activity against the CRF1 receptor, the protons at the...

Location matters: why target location impacts performance in orientation tasks.

This research explores human performance in a spatial orientation task. In three experiments, participants saw a target highlighted in a visual scene and were asked to locate it on a map of the space. Across all of the experiments, the target's location in the visual scene influenced the participants' response times. Generally, response times increased when the target was located farther away f...

Mobility Matters: Identifying Cognitive Demands That Are Sensitive to Orientation

Prior studies have shown benefits of interactions on mobile devices. Device mobility itself changes the nature of the user experience; interactions on mobile devices may present better support for cognition. To better understand cognitive demands related to mobility, the current study investigated presentations on a mobile device for a three-dimensional construction task. The task imposed consi...

Pharmacoeconomics 2006; 24 (10): 953-954